New insights into the role of luteinising hormone in early ovarian follicular growth: a possible tool to optimise follicular recruitment
نویسندگان
چکیده
Evidence shows that luteinising hormone (LH) participates in enhancing the transition from early to antral stage of folliculogenesis. Functional LH receptor was demonstrated be expressed, albeit at a very low level, even smaller follicles during phase traditionally considered gonadotropin-independent suggesting role for accelerating rate progression non-growing and primary preantral/antral stage. Hypogonadotropic-hypogonadism together with other clinical conditions pituitary suppression have been associated reduced functional reserve. The reduction LH, than FSH serum is fact AMH values. This case hypothalamic amenorrhea, pregnancy, long-term GnRH analogue therapy or hormonal contraception. effect seems reversible so after discontinuation drugs, ovarian reserve returns baseline levels. evidence suggests women similar primordial follicle could present different numbers gonadotropins may play fundamental permitting normal throughout noncyclic precise gonadotrophins folliculogenesis as well their use modify must investigated.
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ژورنال
عنوان ژورنال: Reproductive Biomedicine Online
سال: 2023
ISSN: ['1472-6483', '1472-6491']
DOI: https://doi.org/10.1016/j.rbmo.2023.103369